Nurse Practitioner Salary in South Carolina: $123,290 Median (May 2025)
Nurse practitioners in South Carolina earn a median of $123,290 per year — $59.28 an hour — $9,010 below the national NP median of $132,300, ranking #48 of 51 states and D.C. The middle 80% of South Carolina NPs earn between $97,080 and $160,170. Source: U.S. Bureau of Labor Statistics, Occupational Employment and Wage Statistics (OEWS), May 2025 — the federal wage survey, not job-board self-reports.
South Carolina NP pay range (May 2025)
Dark band = middle 50% of South Carolina NPs (25th–75th percentile). Light band = middle 80%. New NPs typically start near the left edge.
NP vs RN Pay in South Carolina
The median NP in South Carolina out-earns the median RN by $40,930 per year (50%). Same state, same license underneath — the difference is the graduate degree and the scope that comes with it.
Compare South Carolina With Any State
Weighing a move, telehealth, or a compact-state license? Put South Carolina side by side with any other NP market.
| May 2025 BLS | South Carolina | Texas |
|---|---|---|
| Median annual salary | $123,290 | $131,670 |
| Median hourly wage | $59.28/hr | $63.31/hr |
| Entry-level range (10th pct) | $97,080 | $96,880 |
| Experienced (75th pct) | $132,220 | $147,660 |
| Top earners (90th pct) | $160,170 | $161,980 |
| NPs employed | 5,670 | 25,970 |
The NP path starts with an RN license
Every NP passed the NCLEX first. If you’re earlier on the ladder: compare South Carolina’s board-approved nursing programs by real first-time pass rates, and see the full earning ladder from CNA to CRNA.
Frequently Asked Questions
How much do nurse practitioners make in South Carolina?
NPs in South Carolina earn a median of $123,290 per year — $59.28 per hour — $9,010 below the national NP median of $132,300 (BLS May 2025). That ranks South Carolina #48 of 51 states and D.C. by median NP pay.
How much more do NPs make than RNs in South Carolina?
The median NP in South Carolina earns $123,290 versus $82,360 for the median RN — a difference of $40,930 per year (50%). The step up requires a master's or doctoral NP program on top of the RN license.
What is a starting NP salary in South Carolina?
New NPs generally start near the lower percentiles: in South Carolina, the 10th percentile is $97,080 and the 25th percentile is $107,930. Most NPs move toward the $123,290 median within their first several years of practice.
How many nurse practitioners work in South Carolina?
5,670 nurse practitioners are employed in South Carolina per the BLS May 2025 estimates.