Nurse Practitioner Salary in Missouri: $129,930 Median (May 2025)
Nurse practitioners in Missouri earn a median of $129,930 per year — $62.47 an hour — $2,370 below the national NP median of $132,300, ranking #35 of 51 states and D.C. The middle 80% of Missouri NPs earn between $100,650 and $162,060. Source: U.S. Bureau of Labor Statistics, Occupational Employment and Wage Statistics (OEWS), May 2025 — the federal wage survey, not job-board self-reports.
Missouri NP pay range (May 2025)
Dark band = middle 50% of Missouri NPs (25th–75th percentile). Light band = middle 80%. New NPs typically start near the left edge.
NP vs RN Pay in Missouri
The median NP in Missouri out-earns the median RN by $48,150 per year (59%). Same state, same license underneath — the difference is the graduate degree and the scope that comes with it.
Compare Missouri With Any State
Weighing a move, telehealth, or a compact-state license? Put Missouri side by side with any other NP market.
| May 2025 BLS | Missouri | Texas |
|---|---|---|
| Median annual salary | $129,930 | $131,670 |
| Median hourly wage | $62.47/hr | $63.31/hr |
| Entry-level range (10th pct) | $100,650 | $96,880 |
| Experienced (75th pct) | $144,640 | $147,660 |
| Top earners (90th pct) | $162,060 | $161,980 |
| NPs employed | 7,710 | 25,970 |
The NP path starts with an RN license
Every NP passed the NCLEX first. If you’re earlier on the ladder: compare Missouri’s board-approved nursing programs by real first-time pass rates, and see the full earning ladder from CNA to CRNA.
Frequently Asked Questions
How much do nurse practitioners make in Missouri?
NPs in Missouri earn a median of $129,930 per year — $62.47 per hour — $2,370 below the national NP median of $132,300 (BLS May 2025). That ranks Missouri #35 of 51 states and D.C. by median NP pay.
How much more do NPs make than RNs in Missouri?
The median NP in Missouri earns $129,930 versus $81,780 for the median RN — a difference of $48,150 per year (59%). The step up requires a master's or doctoral NP program on top of the RN license.
What is a starting NP salary in Missouri?
New NPs generally start near the lower percentiles: in Missouri, the 10th percentile is $100,650 and the 25th percentile is $119,910. Most NPs move toward the $129,930 median within their first several years of practice.
How many nurse practitioners work in Missouri?
7,710 nurse practitioners are employed in Missouri per the BLS May 2025 estimates.