Neurological · Topic 25 of 27
Migraine & Triptans
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Migraine & Triptans
A recurrent, often unilateral, throbbing headache lasting 4 to 72 hours, with nausea, vomiting, photophobia and phonophobia. The dangers are missing an emergency headache and giving a triptan to the wrong client.
What triggers it
A headache diary identifies each client's triggers
One-year prevalence is about 18% in women and 6% in men; migraine usually begins around puberty or young adulthood.
What you'll see
Often unilateral, throbbing, 4 to 72 hours, with nausea and light and sound sensitivity
An attack lasting more than 72 hours is status migrainosus.
Red flags
These headaches are emergencies
Relief from a triptan does not rule out a dangerous cause: a triptan can also relieve a subarachnoid hemorrhage headache. Chest tightness after a triptan is usually noncardiac, but high-risk clients need cardiac evaluation.
Treatment
During an attack: dark, quiet room, cold compress, and treat at the first sign of pain
Dark, quiet room and a cold compress
Treat early, at the first sign of painNSAID or acetaminophen, plus an antiemetic for nausea
Take at onset; it does not prevent migraine
Never within 24 hours of another triptan or an ergotContraindicated in pregnancy
Also with potent CYP3A4 inhibitors: macrolides, protease inhibitorsCGRP antagonists such as erenumab or atogepant are also options
Valproate is teratogenicCombined estrogen contraceptives are contraindicated (US MEC category 4)
Ischemic stroke riskDoses, limits and other drugs
Nursing priorities
Migraine, tension or cluster?
Tension is bilateral and band-like, without nausea; cluster is orbital with tearing
| Migraine | Tension | Cluster | |
|---|---|---|---|
| Where | Often unilateral | Bilateral | Unilateral, orbital |
| Feels like | Throbbing | Band-like pressure | Severe |
| Comes with | Nausea, vomiting, photophobia, phonophobia | No nausea | Tearing and nasal congestion |
| Key clue | Lasts 4 to 72 hours; triptan at onset | Not worsened by physical activity | Occurs in clusters; high-flow 100% oxygen by non-rebreather aborts attacks |
Teach your patient
Sudden "worst headache of my life" is an emergency, not a migraine. Triptans go in at onset, never with CAD, MI, stroke, TIA or uncontrolled hypertension, and frequent acute-drug use causes medication-overuse headache.
Sources · Migraine (Merck Manual) · Approach to the Patient With Headache (Merck Manual) · Medication Overuse Headache (Merck Manual) · Cluster Headache (Merck Manual) · Tension-Type Headache (Merck Manual) · Sumatriptan label (DailyMed) · Ergotamine and caffeine label (DailyMed) · Divalproex label (DailyMed) · Topiramate label (DailyMed) · U.S. Medical Eligibility Criteria for Contraceptive Use, 2024 (CDC) · Consensus Statement 2021 (American Headache Society) · CGRP Position Statement 2024 (American Headache Society) · Treatment of Cluster Headache 2016 (American Headache Society) · SNNOOP10 red flags (Neurology) · Migraine (MedlinePlus) · Follow your facility's protocol for triptan administration.
Migraine & Triptans
Migraine is a recurrent, often unilateral, throbbing headache lasting 4 to 72 hours, with nausea, vomiting, photophobia and phonophobia. Aura, such as flashing lights, visual loss or tingling, comes before the pain in about a quarter of clients, and a headache diary identifies triggers such as stress, sleep change, skipped meals and hormonal shifts. During an attack the client needs a dark, quiet room, a cold compress and treatment at the first sign of pain. Triptans such as sumatriptan treat an attack at onset but are contraindicated with coronary artery disease, prior MI, stroke or TIA, and uncontrolled hypertension, and are never given within 24 hours of another triptan or an ergot. Frequent acute-drug use causes medication-overuse headache, so the client limits acute medication days as directed. A sudden "worst headache of my life," fever with stiff neck, new neurologic deficit, headache after head injury or a new headache in an older adult is an emergency.
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