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Neurological · Topic 25 of 27

Migraine & Triptans

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Neuro · headache

Migraine & Triptans

A recurrent, often unilateral, throbbing headache lasting 4 to 72 hours, with nausea, vomiting, photophobia and phonophobia. The dangers are missing an emergency headache and giving a triptan to the wrong client.

01 · Emergency, act nowSudden "worst headache of my life"
02 · No triptan withCAD, MI, stroke, TIA, uncontrolled hypertension
03 · Medication overuseLimit acute-drug days per week as directed
01

What triggers it

A headache diary identifies each client's triggers

Daily rhythm
StressSleep changeSkipped meals
Hormones
Hormonal shifts
Food and drink
AlcoholAged cheese

One-year prevalence is about 18% in women and 6% in men; migraine usually begins around puberty or young adulthood.

02

What you'll see

Often unilateral, throbbing, 4 to 72 hours, with nausea and light and sound sensitivity

Often unilateral, throbbing headache hallmark
Lasts 4 to 72 hours
Nausea and vomiting
Photophobia (light sensitivity), phonophobia (sound sensitivity)
Aura: flashing lights, visual loss, tingling before the pain about 25% of clients

An attack lasting more than 72 hours is status migrainosus.

03

Red flags

These headaches are emergencies

Sudden "worst headache of my life" emergency
Fever with stiff neck emergency
New neurologic deficit emergency
Headache after head injury emergency
New headache in an older adult emergency
Chest tightness or pressure after a triptan report now
Triptan + SSRI or SNRI: agitation, fever, tachycardia, muscle rigidity stop the drug, report

Relief from a triptan does not rule out a dangerous cause: a triptan can also relieve a subarachnoid hemorrhage headache. Chest tightness after a triptan is usually noncardiac, but high-risk clients need cardiac evaluation.

04

Treatment

During an attack: dark, quiet room, cold compress, and treat at the first sign of pain

Comfortduring an attack

Dark, quiet room and a cold compress

Treat early, at the first sign of pain
Mild attackstart here
NSAID acetaminophen antiemetic

NSAID or acetaminophen, plus an antiemetic for nausea

Triptanmoderate to severe attacks, or when these fail
sumatriptan

Take at onset; it does not prevent migraine

Never within 24 hours of another triptan or an ergot
Ergotcontraindications
ergotamine

Contraindicated in pregnancy

Also with potent CYP3A4 inhibitors: macrolides, protease inhibitors
Preventionfor frequent migraine
propranolol metoprolol topiramate amitriptyline valproate

CGRP antagonists such as erenumab or atogepant are also options

Valproate is teratogenic
Contraceptionmigraine with aura

Combined estrogen contraceptives are contraindicated (US MEC category 4)

Ischemic stroke risk
Doses, limits and other drugs
Oral sumatriptan: second dose at least 2 hours after the first, if some responsemaximum 200 mg in 24 hours
Overuse: triptans, ergots, opioids or combination analgesics on 10 or more days a monthor simple analgesics on 15 or more days a month, for over 3 months
Acute-drug use on more than 2 days a week calls for a preventive plan
Sumatriptan also contraindicated with hemiplegic or basilar migraineand peripheral vascular disease, ischemic bowel disease, Wolff-Parkinson-White syndrome, MAO-A inhibitors within 2 weeks
Cardiovascular contraindication: gepants or lasmiditan can treat the attackgepants: ubrogepant, rimegepant
Offer prevention at 6 or more headache days a month with no disability (AHS 2021)4 or more with some disability, 3 or more with severe disability
AHS 2024: CGRP-targeting therapies are a first-line prevention optionwithout first failing older preventives
Valproate is contraindicated for migraine prevention in pregnancyand in women of childbearing potential not using effective contraception
Topiramate can reduce contraceptive effectiveness and raises kidney stone riskalso increases the risk of oral clefts in exposed infants
05

Nursing priorities

Report an emergency headache: sudden worst, stiff neck, new deficit
Screen for CAD, MI, stroke, TIA, uncontrolled hypertension before a triptan
Check for a triptan or ergot in the last 24 hours
Treat early, at the first sign of pain
Provide a dark, quiet room and a cold compress
Count acute medication days; teach the limit
06

Migraine, tension or cluster?

Tension is bilateral and band-like, without nausea; cluster is orbital with tearing

MigraineTensionCluster
WhereOften unilateralBilateralUnilateral, orbital
Feels likeThrobbingBand-like pressureSevere
Comes withNausea, vomiting, photophobia, phonophobiaNo nauseaTearing and nasal congestion
Key clueLasts 4 to 72 hours; triptan at onsetNot worsened by physical activityOccurs in clusters; high-flow 100% oxygen by non-rebreather aborts attacks
07

Teach your patient

Keep a headache diary to identify your triggers
Treat early, at the first sign of pain
Limit acute medication days per week as directed; keep a count
Report chest tightness or pressure after a triptan
Never take a triptan within 24 hours of another triptan or an ergot
With an SSRI or SNRI: stop and report agitation, fever, rigidity
Migraine with aura: no combined estrogen contraceptives
Pearl

Sudden "worst headache of my life" is an emergency, not a migraine. Triptans go in at onset, never with CAD, MI, stroke, TIA or uncontrolled hypertension, and frequent acute-drug use causes medication-overuse headache.

Sources · Migraine (Merck Manual) · Approach to the Patient With Headache (Merck Manual) · Medication Overuse Headache (Merck Manual) · Cluster Headache (Merck Manual) · Tension-Type Headache (Merck Manual) · Sumatriptan label (DailyMed) · Ergotamine and caffeine label (DailyMed) · Divalproex label (DailyMed) · Topiramate label (DailyMed) · U.S. Medical Eligibility Criteria for Contraceptive Use, 2024 (CDC) · Consensus Statement 2021 (American Headache Society) · CGRP Position Statement 2024 (American Headache Society) · Treatment of Cluster Headache 2016 (American Headache Society) · SNNOOP10 red flags (Neurology) · Migraine (MedlinePlus) · Follow your facility's protocol for triptan administration.

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