Maternal & Newborn · Topic 42 of 48
Neonatal Abstinence Syndrome
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Neonatal Abstinence Syndrome
Withdrawal in a newborn exposed in utero to opioids or other substances. Comfort care comes first, and naloxone is never the answer.
Why it happens
The in-utero supply of a substance — most often an opioid — stops at birth
What causes it
Opioids are the most common cause
When it appears
Usually 1–3 days after birth — can take up to a week
What you'll see
An overexcited nervous system, gut and autonomic system
Scoring & labs
Score at regular intervals — Finnegan or Eat, Sleep, Console
Red flags
Treatment
Swaddle, dim quiet room, rocking, skin-to-skin, pacifier
Keep the parent at the bedside as the main comforter
Small, frequent, higher-calorie feedings
IV fluids if vomiting or dehydratedMorphine most often, tapered slowly
Never give naloxone to this newborn
Added drugs and the course
Nursing priorities
Teach your patient
Breastfeeding fits a parent stable in a methadone or buprenorphine program, without other illicit drug use, and with no contraindication such as HIV infection. Long-term risks include developmental and behavioral problems.
Quiet, dark, swaddled, held by the parent — comfort first, scored often. Morphine only if comfort fails, and never naloxone.
Sources · Neonatal Abstinence Syndrome (StatPearls) · Neonatal abstinence syndrome (MedlinePlus, NLM) · Neonatal Opioid Withdrawal Syndrome (AAP, Pediatrics) · Maternal-Newborn Nursing 25.2 Congenital, Genetic, and Acquired Complications (OpenStax) · Naloxone hydrochloride injection label (DailyMed) · Time to NAS Treatment after Buprenorphine or Methadone Exposure (Drug Alcohol Depend, PMC) · NAS Signs in Methadone- vs Buprenorphine-Exposed Neonates (Addiction, PMC) · Follow your facility's protocol for withdrawal scoring and treatment.
Neonatal Abstinence Syndrome
Neonatal abstinence syndrome is withdrawal in a newborn who was exposed to a substance before birth, most often opioids, and whose supply suddenly stops at delivery. Think of a nervous system turned up too high: a shrill, high-pitched cry, tremors, hypertonia, an exaggerated Moro reflex, frantic but poorly coordinated sucking, vomiting, loose stools, sneezing, yawning, sweating, and tachypnea. Signs usually start one to three days after birth. Heroin tends to show up early, while long-acting methadone and buprenorphine show up later, so those newborns are observed for five to seven days. The nurse scores the newborn regularly with the Finnegan tool or Eat, Sleep, Console, and comfort care always comes first: swaddling, a dim and quiet room, skin-to-skin contact, rooming-in with the parent, a pacifier, and small, frequent feedings. If withdrawal stays severe, the newborn gets an opioid such as morphine, tapered slowly. Never give naloxone to these newborns, because it can trigger seizures. Breastfeeding is encouraged when the parent is stable in treatment, and care for the family stays nonjudgmental.
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