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Maternal & Newborn · Topic 42 of 48

Neonatal Abstinence Syndrome

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Newborn · withdrawal

Neonatal Abstinence Syndrome

Withdrawal in a newborn exposed in utero to opioids or other substances. Comfort care comes first, and naloxone is never the answer.

01 · Never giveNo naloxone — it can trigger seizures
02 · Do firstSwaddle, dim quiet room, skin-to-skin
03 · The hallmarkHigh-pitched cry, tremors, hypertonia
01

Why it happens

The in-utero supply of a substance — most often an opioid — stops at birth

The fetus becomes dependent on the substance in utero
The supply stops at birth → withdrawal
NOWS (neonatal opioid withdrawal syndrome) = the opioid name
02

What causes it

Opioids are the most common cause

Opioids
Heroinshort-acting — signs often within 24 hoursMethadonelong-acting — later signsBuprenorphinelong-acting — later signs
Other substances
BenzodiazepinesNicotineAlcohol
03

When it appears

Usually 1–3 days after birth — can take up to a week

Heroin (short-acting): signs often within 24 hours
Methadone or buprenorphine (long-acting): signs come later
Observe long-acting opioid exposure for 5–7 days
04

What you'll see

An overexcited nervous system, gut and autonomic system

Excessive high-pitched crying, irritability hallmark
Tremors, hypertonia (increased muscle tone) hallmark
Exaggerated Moro reflex (hyperactive reflexes)
Poor feeding — excessive or uncoordinated sucking
Sneezing, nasal stuffiness, frequent yawning
Sweating, fever, tachypnea (fast breathing), mottling
Vomiting, loose stools dehydration risk
Slow weight gain undefined
Rubbed-raw knees, elbows and face from restless movement skin breakdown
05

Scoring & labs

Score at regular intervals — Finnegan or Eat, Sleep, Console

Finnegan score: points for each sign by severity
Eat, Sleep, Console: can the infant eat, sleep, be consoled?
Urine and meconium drug screens identify the exposure
Track weight and hydration
06

Red flags

Seizure report now
Not breathing, parent opioid-dependent: ventilate, no naloxone no naloxone
Scores stay high despite comfort care medication cue
Vomiting with signs of dehydration report now
Watch for respiratory distress and failure to thrive
07

Treatment

Comfortfirst line for every newborn

Swaddle, dim quiet room, rocking, skin-to-skin, pacifier

Rooming-inthe parent comforts

Keep the parent at the bedside as the main comforter

Feedingpoor suck, slow gain

Small, frequent, higher-calorie feedings

IV fluids if vomiting or dehydrated
Opioidif severe despite comfort care
morphine methadone

Morphine most often, tapered slowly

No naloxoneprecipitates withdrawal seizures
naloxone

Never give naloxone to this newborn

Added drugs and the course
Phenobarbital or clonidine for severe or mixed-substance withdrawal
Methadone or buprenorphine: shorter stays than morphine
Treatment lasts 1 week to 6 months; comfort care continues at home
08

Nursing priorities

Score withdrawal at regular intervals
Start comfort care: swaddle, dim quiet room, skin-to-skin
Feed small and often; track weight and hydration
Report a seizure or scores that stay high
Protect the skin: barrier ointment as ordered
Follow state reporting law; give nonjudgmental care
09

Teach your patient

Breastfeeding is encouraged when you are stable in treatment
Swaddle, hold skin-to-skin and keep the room calm at home
Feed small amounts often
Use safe sleep every time — NAS raises SIDS risk
Keep to the plan of safe care made before discharge

Breastfeeding fits a parent stable in a methadone or buprenorphine program, without other illicit drug use, and with no contraindication such as HIV infection. Long-term risks include developmental and behavioral problems.

Pearl

Quiet, dark, swaddled, held by the parent — comfort first, scored often. Morphine only if comfort fails, and never naloxone.

Sources · Neonatal Abstinence Syndrome (StatPearls) · Neonatal abstinence syndrome (MedlinePlus, NLM) · Neonatal Opioid Withdrawal Syndrome (AAP, Pediatrics) · Maternal-Newborn Nursing 25.2 Congenital, Genetic, and Acquired Complications (OpenStax) · Naloxone hydrochloride injection label (DailyMed) · Time to NAS Treatment after Buprenorphine or Methadone Exposure (Drug Alcohol Depend, PMC) · NAS Signs in Methadone- vs Buprenorphine-Exposed Neonates (Addiction, PMC) · Follow your facility's protocol for withdrawal scoring and treatment.

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