Circumcision & Newborn Screening

Newborn screening (NBS) is a state-mandated panel of tests detecting metabolic, endocrine, hematologic, and genetic disorders before symptoms appear. The heel stick specimen should be collected after 24 hours of age with adequate feeding established — specimens collected before 24 hours of age require a repeat regardless of feeding volume, because postnatal metabolic maturation is the primary driver of valid results. All 50 states screen for at least the core panel recommended by ACMG (approximately 35 conditions), including PKU, congenital hypothyroidism, galactosemia, sickle cell disease, and cystic fibrosis. Hearing screening and pulse oximetry screening for critical congenital heart defects (comparing pre-ductal right hand and post-ductal foot saturations; pass is ≥95% with ≤3% difference) are also completed before discharge. For circumcision, the nurse confirms informed parental consent and verifies the newborn is stable. Contraindications include bleeding disorders, hypospadias (foreskin may be needed for surgical repair), and ambiguous genitalia (sex assignment and urologic evaluation are pending). Vitamin K injection must be administered before circumcision to support clotting. Pain management includes non-nutritive sucking with sucrose solution and dorsal penile nerve block or EMLA cream per provider order. Post-procedure care: for Gomco clamp sites, apply petroleum jelly gauze with each diaper change for 24-48 hours; for Plastibell, no petroleum jelly is needed — the ring falls off in 5-8 days and should not be pulled off. Monitor for bleeding (more than a quarter-sized spot is abnormal) and assess urination within 24 hours. A yellowish exudate forming over the glans by day 2-3 is normal granulation tissue, not infection.