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Gastrointestinal · Topic 6 of 20

Irritable Bowel Syndrome (IBS)

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GI · functional disorder

Irritable Bowel Syndrome (IBS)

A functional gut-brain disorder: recurrent abdominal pain tied to defecation, with a change in stool frequency or form. The tissue stays normal, so bleeding, weight loss or fever must be reported.

01 · Not explained by IBSReport rectal bleeding, weight loss, fever
02 · What it doesn't doNo inflammation, no added colon cancer risk
03 · The first teachingSymptom and food diary to find triggers
01

Why it happens

A functional gut-brain disorder: no inflammation, no structural damage

No inflammation or structural damage in the bowel
Does not raise colon cancer risk
More common in women; usually begins in the teens to early adulthood
02

The three subtypes

The main stool pattern names the subtype, and drugs are chosen for that pattern

IBS-C: constipation is the main stool pattern
IBS-D: diarrhea is the main stool pattern
IBS-M: mixed stool pattern
03

What you'll see

Recurrent abdominal pain tied to defecation

Recurrent abdominal pain tied to defecation hallmark
Change in stool frequency
Change in stool form

Bloating, a feeling of incomplete emptying and whitish mucus in the stool also occur; symptoms often worsen during menses.

04

Labs & diagnostics

A positive diagnosis, not only what is left after ruling everything out

Symptom pattern, history, exam and limited testing make the diagnosis

Rome criteria: abdominal pain at least 1 day a week for 3 months, with at least two of: related to defecation, change in stool frequency, change in stool form. With suspected IBS-D, the provider may check celiac serology, fecal calprotectin and CRP to rule out celiac disease and inflammatory bowel disease.

05

Red flags

IBS does not explain these: report them

Rectal bleeding report now
Unintended weight loss report now
Fever report now
Nocturnal symptoms report now
Anemia report now
Onset after about age 50 report now
Family history of colorectal cancer report now
On alosetron: new constipation, rectal bleeding or bloody diarrhea stop alosetron
On alosetron: new or worsening abdominal pain stop alosetron
06

Treatment

Diarrheaconstipation is the common effect
loperamide

Never exceed the loperamide dose

High doses cause torsades de pointes and cardiac arrest
Constipationeases stool passage
polyethylene glycol

Does not reliably relieve the abdominal pain

IBS-Cdiarrhea is the main adverse effect
linaclotide

Empty stomach, at least 30 minutes before a meal

Hold it and report severe diarrhea
Crampingantispasmodic
dicyclomine

Anticholinergic: dry mouth, blurred vision, urinary retention, heat intolerance

Delirium in older adults
Painlow-dose tricyclic
amitriptyline

The low dose targets gut pain, not depression

Expect sedation and anticholinergic effects
Boxed warningischemic colitis, serious constipation complications
alosetron

Stop it and report new constipation or bloody stools

Also report rectal bleeding and new or worsening abdominal pain
Dose limits and other drugs
Alosetron only for women with severe IBS-D unresponsive to conventional therapynot started with constipation; contraindicated with fluvoxamine
Loperamide maximum: 8 mg a day over the counter, 16 mg a day by prescriptionstop it if constipation, distention or ileus develops
Linaclotide contraindicated under 2 years of age (boxed warning: serious dehydration)also with known or suspected mechanical GI obstruction
Rifaximin, a gut-selective antibiotic, treats IBS-D
Eluxadoline treats IBS-D; pancreatitis risk limits itbarred after cholecystectomy and with sphincter of Oddi dysfunction, severe hepatic impairment or heavy alcohol use
Peppermint oil may relax smooth muscle and relieve crampingevidence for probiotics is still limited
07

Nursing priorities

Report rectal bleeding, weight loss, fever, anemia, nocturnal symptoms
Stop alosetron and report new constipation or bloody stools
Keep loperamide within the ordered dose
Match the drug to the client's main stool pattern
Teach the symptom and food diary
08

IBS or IBD?

IBS has normal tissue; inflammatory bowel disease shows visible inflammation

IBSIBD
Bowel tissueNormalVisible inflammation
BleedingNoneCan cause bleeding
Weight lossNoneCan cause weight loss
FeverNoneCan cause fever
NamesIBS-C, IBS-D, IBS-MCrohn's disease, ulcerative colitis
09

Teach your patient

Keep a symptom and food diary to find your triggers
Triggers: gas-producing foods, caffeine, alcohol, fatty foods
Low-FODMAP is a limited trial, ideally with a dietitian
Restrict, reintroduce foods gradually, then personalize
Long-term food restriction risks nutrient deficiencies
Use soluble fiber (psyllium), not insoluble fiber
Increase fiber gradually with fluids to limit gas and bloating
Regular meals, exercise and adequate sleep reduce symptoms
Stress management and CBT reduce symptoms

Psychotherapy is part of care, not a last resort.

Pearl

IBS is pain tied to defecation with normal tissue and no added colon cancer risk. Bleeding, weight loss, fever, anemia or nocturnal symptoms are not IBS: report them.

Sources · Management of Irritable Bowel Syndrome, Clinical Guideline 2021 (ACG) · Irritable Bowel Syndrome (Merck Manual) · Symptoms & Causes of IBS (NIDDK) · Treatment for IBS (NIDDK) · Irritable Bowel Syndrome (Cleveland Clinic) · Alosetron label (DailyMed) · Linaclotide label (DailyMed) · Loperamide label (DailyMed) · Loperamide OTC Drug Facts (DailyMed) · Dicyclomine label (DailyMed) · Follow your facility's protocol for alosetron and antidiarrheal dosing.

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