Gastrointestinal · Topic 6 of 20
Irritable Bowel Syndrome (IBS)
Start here
Tap any line to see why it matters
Irritable Bowel Syndrome (IBS)
A functional gut-brain disorder: recurrent abdominal pain tied to defecation, with a change in stool frequency or form. The tissue stays normal, so bleeding, weight loss or fever must be reported.
Why it happens
A functional gut-brain disorder: no inflammation, no structural damage
The three subtypes
The main stool pattern names the subtype, and drugs are chosen for that pattern
What you'll see
Recurrent abdominal pain tied to defecation
Bloating, a feeling of incomplete emptying and whitish mucus in the stool also occur; symptoms often worsen during menses.
Labs & diagnostics
A positive diagnosis, not only what is left after ruling everything out
Rome criteria: abdominal pain at least 1 day a week for 3 months, with at least two of: related to defecation, change in stool frequency, change in stool form. With suspected IBS-D, the provider may check celiac serology, fecal calprotectin and CRP to rule out celiac disease and inflammatory bowel disease.
Red flags
IBS does not explain these: report them
Treatment
Never exceed the loperamide dose
High doses cause torsades de pointes and cardiac arrestDoes not reliably relieve the abdominal pain
Empty stomach, at least 30 minutes before a meal
Hold it and report severe diarrheaAnticholinergic: dry mouth, blurred vision, urinary retention, heat intolerance
Delirium in older adultsThe low dose targets gut pain, not depression
Expect sedation and anticholinergic effectsStop it and report new constipation or bloody stools
Also report rectal bleeding and new or worsening abdominal painDose limits and other drugs
Nursing priorities
IBS or IBD?
IBS has normal tissue; inflammatory bowel disease shows visible inflammation
| IBS | IBD | |
|---|---|---|
| Bowel tissue | Normal | Visible inflammation |
| Bleeding | None | Can cause bleeding |
| Weight loss | None | Can cause weight loss |
| Fever | None | Can cause fever |
| Names | IBS-C, IBS-D, IBS-M | Crohn's disease, ulcerative colitis |
Teach your patient
Psychotherapy is part of care, not a last resort.
IBS is pain tied to defecation with normal tissue and no added colon cancer risk. Bleeding, weight loss, fever, anemia or nocturnal symptoms are not IBS: report them.
Sources · Management of Irritable Bowel Syndrome, Clinical Guideline 2021 (ACG) · Irritable Bowel Syndrome (Merck Manual) · Symptoms & Causes of IBS (NIDDK) · Treatment for IBS (NIDDK) · Irritable Bowel Syndrome (Cleveland Clinic) · Alosetron label (DailyMed) · Linaclotide label (DailyMed) · Loperamide label (DailyMed) · Loperamide OTC Drug Facts (DailyMed) · Dicyclomine label (DailyMed) · Follow your facility's protocol for alosetron and antidiarrheal dosing.
Irritable Bowel Syndrome (IBS)
Irritable bowel syndrome is a functional gut-brain disorder that causes recurrent abdominal pain tied to defecation, with a change in stool frequency or form. The bowel shows no inflammation or structural damage, which is what separates it from Crohn's disease and ulcerative colitis, and colon cancer risk is not raised. It is more common in women and usually begins in the teens to early adulthood. The subtype follows the main stool pattern, IBS-C, IBS-D or IBS-M, and drugs are chosen for that pattern. The nurse reports anything IBS does not explain: rectal bleeding, unintended weight loss, fever, nocturnal symptoms, anemia, onset after about age 50 or a family history of colorectal cancer. Teaching covers a symptom and food diary, a limited low-FODMAP trial, soluble fiber increased gradually with fluids, and stress management. The client never exceeds the loperamide dose, and stops alosetron and reports new constipation or bloody stools because of its boxed warning.
Loading questions…
Go further
- Commonly confusedCholecystitis vs PancreatitisGallbladder vs pancreas — pain location, labs, and diet differ.
- Commonly confusedCrohn's Disease vs Ulcerative ColitisThe two inflammatory bowel diseases that look alike on an exam but differ in location, pattern, and complications.
- GuideHow to Study for Med-Surg: Stop Memorizing, Start ConnectingMed-surg is the first course where memorizing stops working. Start every topic at the mechanism, climb from know-it to spot-it to act-on-it, and practice questions early at the right difficulty — with a real NGN bowtie to try in-page.
Ready to practice this topic?
Get a personalized study plan built around this topic — free to try, no card needed.