Pediatrics · Topic 5 of 42
Vesicoureteral Reflux (VUR)
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Vesicoureteral Reflux (VUR)
Urine flows back from the bladder into the ureters and kidneys, causing recurrent UTIs and pyelonephritis. The danger is renal scarring.
Why it happens
Urine flows backward from the bladder into the ureters and kidneys
About 1–3% of children have VUR, 30–40% of infants and toddlers with a UTI have it, and up to 25% of siblings of affected children do. It is often first found as hydronephrosis on a prenatal ultrasound, or by screening a sibling.
What you'll see (UTI signs)
Infant signs are nonspecific
Infant
Older child
Labs & diagnostics
The VCUG diagnoses VUR — the urine culture comes first
A renal-bladder ultrasound is recommended after a first febrile UTI in infants and toddlers; VCUG follows an abnormal ultrasound or recurrent febrile UTIs. A DMSA (succimer) nuclear scan shows renal scarring or acute kidney involvement. Before a VCUG: a catheter is placed and the child voids on the X-ray table — a simple honest explanation and a parent nearby reduce distress.
Red flags
Early treatment of a febrile UTI protects the kidneys. Breakthrough febrile UTIs are one reason surgery is considered.
Treatment
Grades I–II often outgrown within 1–5 years
Grades IV–V less likely to resolveLow dose once daily, usually at bedtime
Give every day, even when wellUreteral reimplantation or endoscopic bulking injection
Evidence and follow-up
Nursing priorities
Outgrow it or surgery?
The grade predicts the course
| Mild (I–II) | Severe (IV–V) | |
|---|---|---|
| Course | Often resolves as the child grows, by about age 5 | Less likely to resolve |
| Management | Daily low-dose prophylaxis may be ordered while it resolves | Surgery considered: reimplantation or bulking injection |
Teach the family
A full bowel hinders bladder emptying, raises UTI risk and can delay VUR resolution.
VUR = urine flows back to the kidneys, so every febrile UTI can scar them. Culture before the first antibiotic dose, treat promptly, and give prophylaxis every day.
Sources · Vesicoureteral Reflux (MSD Manual Professional) · Urinary Tract Infection in Children (MSD Manual Professional) · Vesicoureteral Reflux in Infants & Young Children (HealthyChildren.org, AAP) · Vesicoureteral Reflux in Children (University Hospitals Rainbow Babies & Children's) · Bowel and Bladder Training (Memorial Hermann Children's) · Follow your facility's protocol for pediatric urine specimen collection.
Vesicoureteral Reflux (VUR)
Vesicoureteral reflux is the backflow of urine from the bladder into the ureters and sometimes the kidneys, which lets bacteria reach the upper urinary tract and causes recurrent urinary tract infections and pyelonephritis in children. Primary reflux is congenital, from a faulty valve where the ureter enters the bladder, while secondary reflux comes from high bladder pressure. The danger is renal scarring from repeated febrile kidney infections, which leads to hypertension and reduced kidney function later. A voiding cystourethrogram makes the diagnosis, and reflux is graded from I, mild, to V, severe. Many children outgrow mild reflux within a few years; low-dose antibiotic prophylaxis may be given once daily, every day, even when the child is well, and surgery is considered for severe grades or breakthrough infections. Infants show only fever, poor feeding, vomiting or irritability, so the nurse collects a urine culture before the first antibiotic dose, by catheter if the child is not toilet-trained. Teaching covers timed and double voiding, preventing constipation, and reporting a fever of 100.4 °F or higher promptly.
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