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Pediatrics · Topic 5 of 42

Vesicoureteral Reflux (VUR)

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Pediatrics · renal

Vesicoureteral Reflux (VUR)

Urine flows back from the bladder into the ureters and kidneys, causing recurrent UTIs and pyelonephritis. The danger is renal scarring.

01 · The dangerFebrile UTIs scar kidneys → hypertension
02 · Collect firstUrine culture before the first antibiotic
03 · Diagnosed byVCUG — graded I (mild) to V (severe)
01

Why it happens

Urine flows backward from the bladder into the ureters and kidneys

Backflow carries bacteria up → recurrent UTIs and pyelonephritis
Repeated febrile kidney infections scar the kidneys
Scarring → hypertension and reduced kidney function later
Primary (congenital): short ureter tunnel, faulty flap valve
Secondary: high bladder pressure (posterior urethral valves, neurogenic bladder)

About 1–3% of children have VUR, 30–40% of infants and toddlers with a UTI have it, and up to 25% of siblings of affected children do. It is often first found as hydronephrosis on a prenatal ultrasound, or by screening a sibling.

02

What you'll see (UTI signs)

Infant signs are nonspecific

Infant

Fever
Poor feeding and vomiting
Lethargy or irritability

Older child

Dysuria, frequency and urgency
Foul-smelling urine
New wetting accidents
03

Labs & diagnostics

The VCUG diagnoses VUR — the urine culture comes first

Urine culture before the first antibiotic dose before 1st dose
Not toilet-trained: catheterized specimen (bag is unreliable)
VCUG: contrast in by catheter, X-rays during voiding
Reflux is graded I (mild) to V (severe)

A renal-bladder ultrasound is recommended after a first febrile UTI in infants and toddlers; VCUG follows an abnormal ultrasound or recurrent febrile UTIs. A DMSA (succimer) nuclear scan shows renal scarring or acute kidney involvement. Before a VCUG: a catheter is placed and the child voids on the X-ray table — a simple honest explanation and a parent nearby reduce distress.

04

Red flags

Fever 100.4 °F (38 °C) or higher report now
Flank pain or vomiting report now
Painful or frequent urination report now
Febrile UTI despite daily prophylaxis breakthrough — report

Early treatment of a febrile UTI protects the kidneys. Breakthrough febrile UTIs are one reason surgery is considered.

05

Treatment

Waitmild reflux often resolves

Grades I–II often outgrown within 1–5 years

Grades IV–V less likely to resolve
Prophylaxiswhile VUR resolves
TMP-SMX nitrofurantoin

Low dose once daily, usually at bedtime

Give every day, even when well
Surgerygrades IV–V or breakthrough UTIs

Ureteral reimplantation or endoscopic bulking injection

Evidence and follow-up
RIVUR trial: daily TMP-SMX cut recurrent UTIs by about halfbut did not reduce renal scarring at 2 years
Follow-up: blood pressure, urinalysis for protein and blood, creatinine
Periodic renal ultrasound; repeat VCUG or nuclear cystogram every 1–2 years
06

Nursing priorities

Collect the urine culture before the first antibiotic dose
Use a catheterized specimen if not toilet-trained
Treat a febrile UTI promptly — it protects the kidneys
Give prophylaxis every day, even when the child is well
Teach timed and double voiding and constipation prevention
07

Outgrow it or surgery?

The grade predicts the course

Mild (I–II)Severe (IV–V)
CourseOften resolves as the child grows, by about age 5Less likely to resolve
ManagementDaily low-dose prophylaxis may be ordered while it resolvesSurgery considered: reimplantation or bulking injection
08

Teach the family

Give the prophylactic antibiotic every day, even when well
Report fever 100.4 °F (38 °C) or higher promptly
Empty the bladder every 2–3 hours while awake; don't hold urine
Double void: count to 10, then try again
Prevent constipation: water, fiber, a soft stool every day
Finish the full antibiotic course for each UTI
Offer adequate fluids; girls wipe front to back

A full bowel hinders bladder emptying, raises UTI risk and can delay VUR resolution.

Pearl

VUR = urine flows back to the kidneys, so every febrile UTI can scar them. Culture before the first antibiotic dose, treat promptly, and give prophylaxis every day.

Sources · Vesicoureteral Reflux (MSD Manual Professional) · Urinary Tract Infection in Children (MSD Manual Professional) · Vesicoureteral Reflux in Infants & Young Children (HealthyChildren.org, AAP) · Vesicoureteral Reflux in Children (University Hospitals Rainbow Babies & Children's) · Bowel and Bladder Training (Memorial Hermann Children's) · Follow your facility's protocol for pediatric urine specimen collection.

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