Rheumatic Fever
Pathophysiology & Risk Factors
Acute rheumatic fever is not an infection of the heart or the joints — it is an immune reaction to an infection that has already resolved. Two to four weeks after an untreated group A streptococcal throat infection, antibodies raised against the bacterium cross-react with the body's own connective tissue. The inflammation lands in the joints, the skin, the basal ganglia and the heart. Everything except the heart heals completely. Because the throat infection is long gone by the time symptoms appear, a negative throat culture does not rule the disease out.
Signs & Symptoms
Interventions & Priorities
Treatments & Medications
Patient Teaching
Clinical Pearl
The joints hurt and get better; the heart valve gets damaged and stays that way. Finish the antibiotics for strep throat and none of it happens.