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Maternal & Newborn · Topic 3 of 58

Multiple Gestation (Twins & Higher-Order)

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Maternity · antepartum

Multiple Gestation (Twins & Higher-Order)

Two or more fetuses in one pregnancy. The overdistended uterus brings preterm labor before birth and hemorrhage after it; shared-placenta twins add twin-twin transfusion.

01 · Most common riskPreterm labor — twins born ~35 weeks
02 · In laborMonitor both FHRs: confirm two distinct rates
03 · After birthCheck fundal tone: high PPH risk
01

Why it happens

The more the twins share, the higher the risk

Dizygotic (fraternal): two eggs, each with its own placenta
Monozygotic (identical): one egg splits, may share a placenta
Shared placenta (monochorionic) → twin-twin transfusion risk
Shared sac (monoamniotic) → cord entanglement risk

Rare exceptions exist in both directions, so chorionicity is set by ultrasound, not assumed from zygosity.

02

Who gets it

Assisted reproduction is the big one

Risk factors
Assisted reproductive technologyOlder maternal ageHigh parityFamily history of multiplesAfrican American race

Twins make up about 31 of every 1,000 US births (2021).

03

What you'll see

Bigger than dates, sicker than expected

Uterus larger than expected for dates hallmark
More intense nausea and vomiting (higher hCG)
Ultrasound confirms it and shows the placentas and sacs
04

Risks to watch

Preterm labor is the most common complication

Preterm labor and birth: twins average about 35 weeks
Maternal: preeclampsia, gestational diabetes, anemia
Maternal: hyperemesis gravidarum, postpartum hemorrhage
Fetus: growth restriction, low birth weight, birth defects
Fetus: stillbirth; malpresentation is common in labor

Postpartum depression is more common after a multiple birth.

05

Twin-twin transfusion: donor or recipient?

Shared-placenta twins only

Donor twinRecipient twin
SizeSmall—
BloodAnemicPolycythemic
FluidLow amniotic fluidExcess amniotic fluid
Heart—Heart strain

Affects about 10–15% of monochorionic-diamniotic twin pregnancies; fetoscopic laser surgery to seal the shared vessels is the usual treatment.

06

Prenatal monitoring

More frequent prenatal visits
Serial ultrasounds: fetal growth, amniotic fluid, cervical length
Closer blood pressure checks (preeclampsia risk)
07

Red flags

Only one FHR found, or a rate matching the maternal pulse confirm two rates
Signs of preterm labor report now
Boggy fundus or heavy bleeding after birth atony
Monoamniotic twins: cords can tighten at any time sudden fetal death

Preterm labor assessment and tocolysis are covered in preterm labor.

08

Birth and after

Two monitorsone rate per twin

Monitor both fetal heart rates continuously in labor

One twin can be recorded twice
Ready roomfor the twin birth

Have blood available and an operating room ready

Two teamsone per baby

A separate resuscitation team and equipment for each baby

Oxytocinthe uterus is overdistended
oxytocin

Assess fundal tone and bleeding closely; expect oxytocin

Provider decisions
Vaginal birth if the first twin is vertex; cesarean if not, or triplets+
Dichorionic twins: delivery at about 38 weeks
Monochorionic-diamniotic twins: delivery at 34 to 37 6/7 weeks
Monoamniotic twins: inpatient monitoring, cesarean at 32–34 weeks
After the first twin is born, the placenta can separate: watch twin two
09

Nursing priorities

In labor, monitor both FHRs and confirm two distinct rates
After birth, assess fundal tone and bleeding closely
Prepare a separate resuscitation team for each baby
Teach preterm labor signs at every prenatal visit
Check blood pressure closely for preeclampsia
10

Teach your patient

Report the signs of preterm labor right away
Eat more calories and protein
Take one daily prenatal vitamin; add iron if anemia develops
You need more folic acid, iron and calcium
Keep the extra prenatal visits and ultrasounds

Weight gain with twins: 37–54 lb at a healthy pre-pregnancy weight, 31–50 lb if overweight, 25–42 lb with obesity.

Pearl

Two fetuses: two monitors, two distinct heart rates, two resuscitation teams. One overdistended uterus: preterm labor before birth, hemorrhage after it.

Sources · Maternal-Newborn Nursing 12.2 Conditions Limited to Pregnancy (OpenStax) · Maternal-Newborn Nursing 19.3 Obstetrical Conditions Affecting Labor and Birth (OpenStax) · Multifetal Gestation (Merck Manual) · Multiple Pregnancy (Merck Manual Consumer) · Twin Pregnancy (Cleveland Clinic) · Perinatal Anemia (Merck Manual) · Twin-Twin Transfusion Syndrome (CHOP) · Multiple Gestation: Labor and Delivery (GLOWM) · Being Pregnant with Twins, Triplets and Other Multiples (March of Dimes) · Lethal Cord Entanglement (PMC) · Medically Indicated Late-Preterm and Early-Term Deliveries, Committee Opinion 831 (ACOG) · Follow your facility's protocol for twin births.

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