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Cardiovascular · Topic 6 of 38

Cardiomyopathy (Dilated, Hypertrophic, Restrictive)

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Cardiac · heart muscle

Cardiomyopathy (Dilated, Hypertrophic, Restrictive)

Disease of the heart muscle itself, in three types: dilated, hypertrophic and restrictive. All three can cause heart failure, dysrhythmias and sudden cardiac death.

01 · The safety ruleHCM: no nitrates, digoxin or dehydration
02 · Most commonDilated: weak, enlarged ventricles, low EF
03 · Sudden deathHCM: #1 sudden death in athletes under 35
01

Three types

Dilated can't squeeze; hypertrophic and restrictive can't fill

DilatedHypertrophic (HCM)Restrictive
VentricleEnlarged and weakThick wall and septum, stiffStiff, not dilated
Fails atSqueezing (systolic dysfunction, low EF)Filling (diastolic dysfunction) + outflow blockFilling (diastolic dysfunction)
How commonThe most common typeUsually inherited (autosomal dominant)The least common type
Classic causeAlcohol, myocarditis, pregnancy, doxorubicinAn inherited geneAmyloidosis
02

What causes it

Dilated has many causes; HCM is inherited

Dilated
Coronary artery diseaseHeavy alcohol or cocaine useViral myocarditisPregnancy (peripartum)last month of pregnancy to 5 months after deliveryDoxorubicincardiotoxic chemotherapyInherited genes
Hypertrophic
Inherited, autosomal dominanteach child has a 50% chance
Restrictive
Amyloidosis
03

What you'll see

Dilated looks like heart failure; HCM shows up on exertion

Dilated: heart-failure signs hallmark
HCM: dyspnea on exertion (the most common symptom) hallmark
HCM: chest pain, palpitations, dizziness
HCM: syncope (fainting) — during exertion, report now
HCM murmur louder with Valsalva or standing from a squat
HCM murmur softer with squatting or hand grip

Peripartum cardiomyopathy arises from the last month of pregnancy to 5 months after delivery: report new dyspnea, edema or fatigue in that window.

04

Red flags

Fainting during exertion in a patient with HCM report now
Nitrate, vasodilator or digoxin ordered for a patient with HCM hold + clarify
Dehydration or aggressive diuresis in HCM worsens obstruction
New atrial fibrillation or ventricular dysrhythmia dysrhythmia
New dyspnea, edema or fatigue late in pregnancy or up to 5 months postpartum peripartum?

In HCM, anything that lowers preload or raises contractility worsens the left ventricular outflow obstruction.

05

Treatment

Rate controlslower rate, longer filling in HCM
verapamil diltiazem

Beta-blocker or verapamil/diltiazem for HCM

ICDprevents sudden cardiac death

ICD when ventricular dysrhythmia risk is high

Anticoagulantatrial fibrillation or mural thrombus

Anticoagulation for AF or a clot inside the heart

Hydrationkeeps preload up in HCM

Prevent dehydration in HCM

Aggressive diuresis worsens the obstruction
Advanced therapy and restrictive care
Dilated = HFrEF therapy: beta-blocker, ARNI/ACE inhibitor/ARB, MRA, SGLT2iplus diuretics; an ICD is recommended when the EF stays 35% or less despite therapy
Obstructive HCM: mavacamten, septal myectomy or alcohol septal ablationalcohol septal ablation carries a higher risk of complete heart block
Restrictive: expect JVD, edema, ascites — give diuretics cautiouslypreload-dependent; over-diuresis drops cardiac output and blood pressure
Amyloid heart disease: digoxin toxicity even at therapeutic levelsdigoxin is generally avoided in restrictive cardiomyopathy
End stage: left ventricular assist device (LVAD) or heart transplant
Takotsubo (stress) cardiomyopathy usually recovers within weeksfollows extreme emotional or physical stress; transthyretin amyloid cardiomyopathy is more common in Black men
06

Nursing priorities

HCM: hold nitrates, vasodilators and digoxin and clarify
HCM: prevent dehydration and aggressive diuresis
Monitor the rhythm for atrial fibrillation and ventricular dysrhythmias
Weigh daily and watch for heart-failure signs
Pace activity with rest periods
Screen first-degree relatives of an HCM patient: echo and ECG

For general heart-failure care, see the heart-failure topics.

07

Teach your patient

HCM: stay well hydrated and avoid dehydration
HCM: avoid heavy meals, alcohol and strenuous exertion
Clear any exercise plan with your cardiologist
Report fainting during exercise right away
Family members need screening — each child has a 50% chance
Weigh yourself every day

Textbooks say avoid strenuous or competitive exercise; 2024 AHA/ACC HCM guidance favors light-to-moderate exercise and shared decisions on competitive sport with an HCM specialist.

Pearl

Dilated can't squeeze; hypertrophic and restrictive can't fill. In HCM, anything that lowers preload or raises contractility worsens the obstruction — no nitrates, digoxin or dehydration.

Sources · Types of Cardiomyopathy (NHLBI) · Dilated Cardiomyopathy (Merck Manual Professional) · Dilated cardiomyopathy (MedlinePlus) · Hypertrophic Cardiomyopathy (Merck Manual Professional) · Hypertrophic Cardiomyopathy (Cleveland Clinic) · Restrictive Cardiomyopathy (Merck Manual Professional) · Lanoxin (digoxin) label (DailyMed) · Follow your facility's protocol for cardiac monitoring.

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