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Word-solving strategies · Topic 14 of 14

Roots & Suffixes

Body-Part Roots

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Vocabulary · roots

Body-Part Roots

A body-part root names the organ: cardi/o heart, hem/o blood, gastr/o stomach, hepat/o liver, nephr/o kidney.

01 · Heartcardi/o = heart
02 · Bloodhem/o, hemat/o = blood
03 · Liverhepat/o = liver
01

Most-tested word parts

cardi/o = heart — cardiology, cardiac, tachycardia
hem/o = blood (also hemat/o) — hemoglobin, hemorrhage, hematology
gastr/o = stomach — gastric, gastritis
hepat/o = liver — hepatitis, hepatic
nephr/o = kidney — nephrology, nephritis
02

More word parts

ren/o = kidney — renal, adrenal
angi/o = vessel (blood vessel) — angioplasty, angiogram
arteri/o = artery — arterial, arteriosclerosis
ven/o = vein — venous, intravenous, venipuncture
enter/o = intestine (usually small) — enteritis, gastroenteritis
cyst/o = bladder, fluid-filled sac — cystitis, cystoscopy
pulmon/o = lung — pulmonary, pulmonologist
pneum/o = lung, air — pneumonia, pneumothorax
oste/o = bone — osteoporosis, osteoarthritis
arthr/o = joint — arthritis, arthroscopy
my/o = muscle — myalgia, myocardium
derm/o = skin (also dermat/o) — dermatology, epidermis, dermal
neur/o = nerve — neurology, neuralgia, neuron
encephal/o = brain — encephalitis, electroencephalogram
crani/o = skull — cranial, craniotomy
ophthalm/o = eye — ophthalmology, ophthalmoscope
ot/o = ear — otitis, otalgia
rhin/o = nose — rhinitis, rhinoplasty
or/o = mouth — oral, oropharynx
mast/o = breast — mastectomy, mastitis
hyster/o = uterus — hysterectomy, hysteroscopy
03

How to answer

Split it: prefix + root + suffix; define the suffix first — peri/card/itis
04

Two roots, one organ

Commonly confused
Root 1Root 2
Kidneynephr/o (nephritis)ren/o (renal)
Lungpneum/o (pneumonia)pulmon/o (pulmonary)
Skinderm/o (dermal)dermat/o (dermatology)
Bloodhem/o (hemoglobin)hemat/o (hematology)
Pearl

Find the root and you find the organ: hepat/itis is an inflamed liver, nephr/itis an inflamed kidney.

Sources · MedlinePlus (NLM) — Appendix A: Word Parts and What They Mean · LibreTexts, The Language of Medical Terminology — 1.3 Combining Forms · LibreTexts, The Language of Medical Terminology (Sturdy & Erickson) — 1.1 Basic Word Structure · LibreTexts, The Language of Medical Terminology — 1.2 Medical Language Rules · Collins English Dictionary — oro- (combining form) · Union Test Prep — HESI Vocabulary study guide, p. 3 (medical prefixes and suffixes) · Union Test Prep — HESI Vocabulary study guide, p. 1 (general prefixes, suffixes, roots) · Built from the verified NurseSavvy HESI A2 fact map (facts reviewed 2026-10-16). HESI is a trademark of Elsevier; NurseSavvy is not affiliated with Elsevier.

Other Common Roots

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Vocabulary · roots

Other Common Roots

Roots for disease, color and substances: path/o disease, carcin/o cancer, erythr/o red, leuk/o white, glyc/o sugar.

01 · Diseasepath/o = disease
02 · Rederythr/o = red (erythrocyte)
03 · Whiteleuk/o = white (leukocyte)
01

Most-tested word parts

path/o = disease — pathology, pathogen
carcin/o = cancer — carcinoma, carcinogen
erythr/o = red — erythrocyte, erythema
leuk/o = white — leukocyte, leukemia
glyc/o = sugar, glucose — hyperglycemia, glycogen
02

More word parts

onc/o = tumor — oncology, oncologist
necr/o = death — necrosis, necrotic
melan/o = black, dark — melanin, melanoma
cyan/o = blue — cyanosis, cyanotic
lact/o = milk — lactation, lactose
lip/o = fat — lipid, lipoma, liposuction
hydr/o = water — dehydration, hydrotherapy
therm/o = heat, temperature — thermometer, hypothermia
pyr/o = fever, fire — pyrexia, antipyretic
kinesi/o = movement — kinesiology, dyskinesia
phag/o = eating, swallowing — dysphagia, phagocyte
psych/o = mind — psychology, psychiatry
gen/o = producing, origin, formation — pathogen, carcinogenic, genetic
chron/o = time — chronic, chronological
scler/o = hard — arteriosclerosis, scleroderma
toxic/o = poison — toxicology, toxicity
gynec/o = woman, female — gynecology, gynecologist
aud/i = hearing (also audi/o) — audible, audiology, audiogram
spir/o = breathe, breath — spirometer, respiration
03

The rules

Combining vowel o: keep before a consonant, drop before a vowel — leuk/o/cyte
04

Erythr/o or leuk/o?

Commonly confused
erythr/oleuk/o
ColorRedWhite
Blood cellerythrocyte (red blood cell)leukocyte (white blood cell)
Another worderythema (redness)leukemia
Pearl

Color roots name blood cells: erythr/o/cyte is red, leuk/o/cyte is white.

Sources · MedlinePlus (NLM) — Appendix A: Word Parts and What They Mean · LibreTexts, The Language of Medical Terminology — 1.3 Combining Forms · LibreTexts, The Language of Medical Terminology — 1.2 Medical Language Rules · LibreTexts, The Language of Medical Terminology (Sturdy & Erickson) — 1.1 Basic Word Structure · LibreTexts, The Language of Medical Terminology — 3.4 Additional Prefixes · LibreTexts, The Language of Medical Terminology — 2.1 Suffixes for Symptoms · LibreTexts, The Language of Medical Terminology — 2.3 Additional Suffixes · Collins English Dictionary — toxico- (combining form) · Collins English Dictionary — audio / audio- (combining form) · LibreTexts, The Language of Medical Terminology — 2.2 Suffixes for Treatment Procedures · Collins English Dictionary — spiro- (combining form) · Collins English Dictionary — pyro- (combining form) · Union Test Prep — HESI Vocabulary study guide, p. 3 (medical prefixes and suffixes) · Union Test Prep — HESI Reading Comprehension study guide, p. 2 (context clues, word analysis) · Built from the verified NurseSavvy HESI A2 fact map (facts reviewed 2026-10-16). HESI is a trademark of Elsevier; NurseSavvy is not affiliated with Elsevier.

Suffixes

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Vocabulary · suffixes

Suffixes

A suffix at the end names the condition or procedure: -itis inflammation, -algia pain, -ectomy removal, -otomy cutting into, -ostomy opening.

01 · Inflamed-itis = inflammation
02 · Removal-ectomy = remove (cut out)
03 · Cut or open-otomy = cut into (incision)
01

Most-tested word parts

-itis = inflammation — appendicitis, arthritis, tonsillitis
-ectomy = surgical removal — appendectomy, tonsillectomy
-otomy = cutting into (incision) — tracheotomy, craniotomy
-ostomy = surgical opening — colostomy, tracheostomy
-algia = pain — neuralgia, myalgia, arthralgia
02

More word parts

-osis = abnormal condition — cyanosis, necrosis, osteoporosis
-emia = blood condition — anemia, leukemia, hyperglycemia
-penia = deficiency, too few — leukopenia, thrombocytopenia
-megaly = enlargement — cardiomegaly, hepatomegaly
-oma = tumor, mass — carcinoma, lipoma, hematoma
-pathy = disease — neuropathy, myopathy
-rrhea = flow, discharge — diarrhea, rhinorrhea
-plasty = surgical repair — rhinoplasty, angioplasty
-scopy = looking inside, visual exam — endoscopy, colonoscopy
-gram = a record, image — electrocardiogram, mammogram
-centesis = puncture to remove fluid — amniocentesis, thoracentesis
-lysis = breakdown, destruction — hemolysis, dialysis
-logy = study of — biology, cardiology
-ist = one who (a specialist) — pharmacist, dentist
-cyte = cell — erythrocyte, leukocyte
-ic = pertaining to — gastric, pelvic
-able = able to be, capable of — treatable, curable
-less = without — painless, sleepless
-ful = full of — painful, helpful
-ness = state of being — weakness, dizziness
-ment = condition, action or result — treatment, impairment
03

The rules

The suffix tells the word's job: condition, procedure, part of speech or person
04

-ectomy or -otomy?

Commonly confused
-ectomy-otomy
MeaningCut out, removeCut into
Is the part removed?Yes, it is taken outNo, it is only cut into
Exampletonsillectomycraniotomy
Another exampleappendectomytracheotomy
Pearl

Remove, cut, open: -ectomy takes it out, -otomy cuts into it, -ostomy makes an opening.

Sources · MedlinePlus (NLM) — Appendix A: Word Parts and What They Mean · LibreTexts, The Language of Medical Terminology — 2.1 Suffixes for Symptoms · LibreTexts, The Language of Medical Terminology — 2.2 Suffixes for Treatment Procedures · LibreTexts, The Language of Medical Terminology — 1.4 Suffixes · LibreTexts, The Language of Medical Terminology (Sturdy & Erickson) — 1.1 Basic Word Structure · LibreTexts, The Language of Medical Terminology — 2.3 Additional Suffixes · Cambridge Dictionary — less (incl. the suffix -less) · Union Test Prep — HESI Vocabulary study guide, p. 3 (medical prefixes and suffixes) · Union Test Prep — HESI Vocabulary study guide, p. 1 (general prefixes, suffixes, roots) · Union Test Prep — HESI Reading Comprehension study guide, p. 2 (context clues, word analysis) · Built from the verified NurseSavvy HESI A2 fact map (facts reviewed 2026-10-16). HESI is a trademark of Elsevier; NurseSavvy is not affiliated with Elsevier.

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