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guide · 12 min read

Free AG-ACNP Practice Questions (With Explanations)

By David Zimmerman, RN and the NurseSavvy team

Clinically reviewed by David Zimmerman · RN · MSN, University of Arizona · BA in Education, Siena College

Product and source claims checked · How we review

10 board-style AG-ACNP questions, free. Answer each one, then read why every option is right or wrong.

In 30 seconds

  1. 1Single best answer with four options, the same format as both exams.
  2. 2Mixed systems first, then the professional role, which is 33% of the ANCC exam.
  3. 3Written fresh by NurseSavvy from our verified fact sheets. They are not real exam questions.

1. Cardiovascular · STEMI

Sample question · Cardiovascular · STEMIBoard style

A patient arrives at a hospital without a cath lab 2 hours after chest pain began. The ECG shows ST elevation in V1–V4. Transfer for PCI would take about 150 minutes from first contact. The patient has no bleeding risk factors. The best reperfusion plan is:

2. Shock & sepsis · Septic shock

Sample question · Shock & sepsis · Septic shockBoard style

A patient with pneumonia has a MAP of 58 mmHg and a lactate of 4.1 mmol/L after 30 mL/kg of balanced crystalloid. Only a peripheral IV is in place. The nurse practitioner should:

3. Pulmonary · ARDS

Sample question · Pulmonary · ARDSBoard style

Three days after severe pancreatitis began, an intubated patient has bilateral opacities not explained by heart failure. On PEEP 10 cmH₂O and FiO₂ 0.6, the PaO₂ is 72 mmHg. By the Berlin definition, this ARDS is:

4. Renal & electrolytes · Hyperkalemia

Sample question · Renal & electrolytes · HyperkalemiaBoard style

A patient with end-stage kidney disease missed dialysis. Potassium is 7.2 mEq/L, and the monitor shows a widening QRS with absent P waves. The first medication to give is:

5. Endocrine · DKA

Sample question · Endocrine · DKABoard style

A patient with DKA has a glucose of 480 mg/dL, pH 7.12 and potassium 3.1 mmol/L. IV fluids are running. The next step is to:

6. Neurology · Ischemic stroke

Sample question · Neurology · Ischemic strokeBoard style

A patient last known well 2 hours ago has a disabling aphasia. Noncontrast CT shows no hemorrhage and glucose is 132 mg/dL. Blood pressure is 196/114 mmHg. Before giving tenecteplase, the nurse practitioner should:

7. Hematology · HIT

Sample question · Hematology · HITBoard style

On day 7 of IV unfractionated heparin after surgery, a patient’s platelets fall from 240,000 to 95,000/mcL and a new calf DVT is found. The 4Ts score is 7. The best plan is to stop heparin and:

8. Electrolytes · Hyponatremia

Sample question · Electrolytes · HyponatremiaBoard style

A patient has a serum sodium of 114 mEq/L of unknown duration and mild confusion. The highest safe rise in sodium over the first 24 hours, counting the initial rise, is:

9. Professional role · Research statistics

Sample question · Professional role · Research statisticsBoard style

In a trial, 12% of patients on placebo and 8% of patients on a new drug died within a year. The number needed to treat to prevent one death is:

10. Professional role · Prescribing

Sample question · Professional role · PrescribingBoard style

At discharge after hip surgery, a patient asks for refills on an oxycodone prescription to last until the follow-up visit. The nurse practitioner should explain that:

What to do next

Missed one? Open its topic’s cheat sheet from the link under the question, then try the official samples from ANCC and the AACN handbook.

Try it now

Sources

  1. ANCC, AGACNP sample test questions, checked November 6, 2026
  2. ANCC, AGACNP Test Content Outline, effective March 17, 2025
  3. AACN, ACNPC-AG Exam Handbook, July 2026 (test plan and sample questions)

AGACNP-BC is a credential of the American Nurses Credentialing Center (ANCC). ACNPC-AG is a credential of AACN Certification Corporation. NurseSavvy is not affiliated with or endorsed by ANCC, AACN or any prep company named here.

Common questions

Are these real AG-ACNP exam questions?

No. NurseSavvy wrote them from its verified fact sheets in the single-best-answer format both exams use. For official samples, see ANCC’s sample test questions and the AACN exam handbook.

Missed one? Read its cheat sheet.

One full 175-question ANCC or AACN practice test free, with a score for each domain. Every one of the 328 topics has a free cheat sheet too.

Take a free practice test