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NurseSavvy Cheat SheetDisease

Meningitis

Inflammation of the meninges from bacterial, viral, or fungal organisms. Bacterial meningitis (most often Neisseria meningitidis or Streptococcus pneumoniae) is a medical emergency with 15-30% mortality even when treated; viral meningitis is usually self-limiting.

EarlyProgresses →
fever Hallmark
severe headache
nuchal rigidity Hallmark
stiff neck; classic triad
photophobia
positive Kernig sign
resistance/pain extending knee with hip flexed 90 degrees
positive Brudzinski sign
neck flexion triggers hip/knee flexion
Late / Severe
altered mental status Hallmark
completes classic triad
petechial rash
non-blanching; meningococcal septicemia
seizures

CSF findings: bacterial vs viral meningitis

BacterialViral
Appearancecloudy / turbidclear
WBC differentialneutrophil predominancelymphocyte predominance
Proteinmarkedly elevatednormal to mildly elevated
Glucosedecreasednormal
Opening pressureelevatednormal to mildly elevated

Bacterial

Appearance
cloudy / turbid
WBC differential
neutrophil predominance
Protein
markedly elevated
Glucose
decreased
Opening pressure
elevated

Viral

Appearance
clear
WBC differential
lymphocyte predominance
Protein
normal to mildly elevated
Glucose
normal
Opening pressure
normal to mildly elevated
droplet precautions
suspected bacterial; private room, surgical mask within 3 feet
draw cultures then give antibiotics
do not delay antibiotics for results
prompt empiric IV antibiotics
time to antibiotics is key prognostic factor
neurologic checks every 1-2 hours
watch for deterioration / rising ICP
seizure precautions
dim, quiet environment
reduce photophobia-related agitation
empiric IV antibiotics
started immediately after cultures
ceftriaxone
common empiric agent
IV dexamethasone
guideline adjunct; give with or just before the first antibiotic dose (isolation + antibiotics remain the top opening priorities)
supportive care for viral
viral is self-limiting
meningococcal vaccination
prevention, esp. adolescents/college students
chemoprophylaxis for close contacts
rifampin, ciprofloxacin, or ceftriaxone
droplet precautions stop at 24 hours
after effective antibiotic therapy begins
report worsening headache or confusion
cerebral edema
SIADH
seizures
hearing loss
Report Nowescalate immediately
increased intracranial pressure
declining LOC, widening pulse pressure, bradycardia
petechial or purpuric rash
meningococcal septicemia
septic shock
disseminated intravascular coagulation
DIC with purpura fulminans
rapidly declining level of consciousness

Clinical Pearl

Kernig = Knee (can't straighten it); Brudzinski = Brain-to-knee (flex the neck, the knees follow). Bacterial CSF is cloudy with LOW glucose; viral is clear with NORMAL glucose.

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