GI Bleeding — Upper vs Lower
Pathophysiology & Risk Factors
GI bleeding is classified by its origin relative to the ligament of Treitz. Upper bleeds (above the landmark — esophagus, stomach, duodenum) typically produce hematemesis and melena; lower bleeds (below — colon, rectum) typically produce hematochezia. A brisk upper bleed can also produce hematochezia, so bright-red rectal bleeding with hemodynamic instability should raise suspicion for an upper source.
Upper vs Lower GI Bleed
Upper GI bleed
- Source (vs ligament of Treitz)
- Above — esophagus, stomach, duodenum
- Common causes
- PUD, varices, gastritis
- Emesis
- Hematemesis (bright red or coffee-ground)
- Stool
- Melena (black, tarry, foul)
- BUN:Cr ratio
- Elevated >20:1 (digested blood)
- Definitive workup
- EGD / upper endoscopy
Lower GI bleed
- Source (vs ligament of Treitz)
- Below — colon, rectum
- Common causes
- Diverticulosis, angiodysplasia, hemorrhoids, cancer
- Emesis
- None
- Stool
- Hematochezia (bright red or maroon)
- BUN:Cr ratio
- Less elevated
- Definitive workup
- Colonoscopy
Signs & Symptoms
Diagnostics & Labs
Monitor
Diagnostic
Interventions & Priorities
Treatments & Medications
Contraindications
Patient Teaching
Clinical Pearl
Hematemesis + melena + a high BUN:Cr points upper; bright-red rectal bleeding points lower. Tachycardia rises before the BP falls — resuscitate before you scope.