Hyponatremia
Pathophysiology & Risk Factors
Hyponatremia is serum sodium below 135 mEq/L. Sodium is the primary extracellular electrolyte controlling water balance, so low sodium usually means too much water relative to sodium — diluted blood. Water shifts into cells by osmosis, swelling them; the brain is most vulnerable because the skull confines it. Symptoms track how fast sodium falls, not just how low it goes.
Signs & Symptoms
Diagnostics & Labs
mEq/L
Interventions & Priorities
Treatments & Medications
Same Na+, opposite treatment — volume status decides
Hypovolemic
- Exam findings
- Poor turgor, dry membranes, orthostasis
- Water balance
- Sodium loss > water loss
- Treatment
- 0.9% normal saline
Euvolemic (SIADH)
- Exam findings
- No edema, no orthostatic changes
- Water balance
- Free water retention
- Treatment
- Fluid restriction
Hypervolemic
- Exam findings
- Pedal edema, JVD, crackles
- Water balance
- Water retained > sodium
- Treatment
- Fluid restriction + diuretics
Patient Teaching
Complications
Clinical Pearl
Low sodium = swollen, waterlogged brain. Restrict water first, replace sodium slowly — correcting too fast is the real danger.