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Conjunctivitis — Bacterial vs Viral

Conjunctivitis is inflammation of the conjunctiva, classified by etiology: bacterial, viral, or allergic. The discharge tells you the type and the treatment — purulent = bacterial, watery = viral, itchy = allergic. Bacterial and viral forms are both highly contagious and spread by direct contact with eye secretions and fomites.

Bacterial vs Viral vs Allergic

BacterialViralAllergic
DischargePurulent yellow-greenWatery clearWatery, stringy
HallmarkLids crusted/stuck on wakingPreauricular node + URIItching
LateralityOne eye, often spreadsOften bilateralBilateral
TreatmentTopical antibiotic drops/ointmentSupportive, self-limitedAntihistamine drops, avoid allergen
CompressWarm (loosen crusts)Cool (comfort)Cool (comfort)

Bacterial

Discharge
Purulent yellow-green
Hallmark
Lids crusted/stuck on waking
Laterality
One eye, often spreads
Treatment
Topical antibiotic drops/ointment
Compress
Warm (loosen crusts)

Viral

Discharge
Watery clear
Hallmark
Preauricular node + URI
Laterality
Often bilateral
Treatment
Supportive, self-limited
Compress
Cool (comfort)

Allergic

Discharge
Watery, stringy
Hallmark
Itching
Laterality
Bilateral
Treatment
Antihistamine drops, avoid allergen
Compress
Cool (comfort)

Diagnostic

Clinical diagnosis
discharge type guides etiology
Gram stain and culture
suspected neonatal or severe disease

Monitor

Visual acuity assessment
after infection resolves
Strict hand hygiene Hallmark
single most effective prevention measure
Avoid touching or rubbing eyes
No sharing towels or pillows
Remove contact lenses
Warm compresses for bacterial crusting
Cool compresses for viral comfort
Contact precautions
bacterial and viral
Erythromycin ophthalmic ointment
routine bacterial cases
Fluoroquinolone drops
contact lens wearers or corneal concern
Supportive care for viral
artificial tears, cool compresses; no antibiotic benefit
Antihistamine eye drops
allergic
Mast cell stabilizer drops
allergic
Systemic azithromycin or erythromycin
chlamydial ophthalmia neonatorum; topical insufficient
Erythromycin 0.5% prophylaxis
all newborns within 1 hour of birth
Meticulous handwashing
before and after touching eyes
Do not touch or rub the eyes
Pull down lower lid, look up, instill in conjunctival sac
correct drop technique
Avoid dropping onto the cornea
triggers blink, expels medication
Inner canthus pressure 1-2 minutes
reduces systemic absorption
Complete the full antibiotic course
even after symptoms resolve
Discard used eye makeup
School exclusion until 24 hours on antibiotics
bacterial, per school policy
Keratitis
Anterior uveitis
Corneal perforation
gonococcal ophthalmia neonatorum
Permanent vision loss
Report Nowescalate immediately
Photophobia
suggests keratitis or uveitis
Decreased visual acuity
Visible corneal opacity
Severe eye pain
Profuse purulent neonatal discharge
gonococcal ophthalmia neonatorum, day 2-5; blindness risk

Clinical Pearl

Goopy and green — give antibiotics. Watery and weepy — wash hands and wait. The discharge tells you the treatment, and both bacterial and viral are very contagious, so hand hygiene comes first.

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