Mitral Valve Disorders
Pathophysiology & Risk Factors
The mitral valve sits between the left atrium and left ventricle. In stenosis the leaflets thicken and fuse (classically from prior rheumatic fever), obstructing diastolic flow into the ventricle; the left atrium dilates and blood backs up into the lungs. In regurgitation the valve fails to close, so blood leaks backward into the left atrium during systole, dilating both the atrium and ventricle from volume overload. Both cause pulmonary congestion first, and both predispose to atrial fibrillation.
Mitral stenosis vs regurgitation
Mitral stenosis
- Valve problem
- Stuck shut, won't open
- Murmur timing
- Diastolic
- Murmur quality
- Low-pitched rumble
- Best heard
- Apex with bell, left lateral decubitus
- Classic cause
- Rheumatic fever
- Chamber affected
- Left atrium dilates
Mitral regurgitation
- Valve problem
- Leaks open, won't close
- Murmur timing
- Systolic (holosystolic)
- Murmur quality
- High-pitched blowing
- Best heard
- Apex, radiates to left axilla
- Classic cause
- Valve closure failure
- Chamber affected
- Left atrium + ventricle dilate
Signs & Symptoms
Diagnostics & Labs
Diagnostic
Monitor
Interventions & Priorities
Treatments & Medications
Patient Teaching
Complications
Clinical Pearl
Stenosis = stuck shut = diastolic rumble; regurgitation = leaks open = systolic blow. Match the murmur to the phase when the valve should be doing the opposite.